Scientists claim, the missing memory of Alzheimer's patient is possible

Scientists claim, the missing memory of Alzheimer's patient is possible


A study has found a new approach to Alzheimer's disease (AD), which can eventually make it possible to bring back lost memory (memory loss). The loss of memory is a sample of symptoms after the disease. Under the leadership of the University of Buffalo, it was found that by focusing on gene changes due to other gene influences other than DNA sequences, which is called epigenetics, it was possible to bring back the lack of memory in a animal model of the disease.

Senior author Zhen Yan said that they have not only identified epigenetic factors which contribute to memory loss but have also found ways to temporarily retrieve them in an animal model of the disease.

The study, which was published in the brain journal, was carried out on the mouse model of Gene mutation for familier Alzheimer's disease, where more than one member of a family had a disease, and even after death, brain tissue had Alzheimer's disease. .

Zen Yan says that "We found that in Alzheimer's disease, many subunits of glutamate receptors are regulated in the frontal cortex (the frontal cortex), which inhibit stimulating signals, which inhibit working memory,"

Researchers also found that the loss of glutamate receptors is the result of an epigenetic process, known as suppressive histone modification, which increases in Alzheimer's disease. The researchers studied the models of both animals that they studied and postmortem in posterior tissues of Alzheimer's disease.

Alzheimer's disease is an irreversible, progressive brain disorder that gradually destroys memory, inhibits the ability to eventually complete simple tasks. Alzheimer's disease is the most common form of dementia. There are no available treatments to prevent or reverse the progression of Alzheimer's disease, which gets worse as it progresses, and eventually leads to death.